"Tailoring the metabolism against mutations"

Note: Pizza served at 11:30 AM
Speaker: Natali Gulbahce, Northeastern University/Harvard Medical School

When: November 9, 2007 (Fri), 12:00PM to 01:00PM (add to my calendar)
Location: SCI 352
Hosted by: William Klein

This event is part of the Biophysics/Condensed Matter Seminar Series.

Abstract:

Biological systems have been natural application grounds for the recent
progress made in the statistical physics of complex networks. Structural
properties of metabolic and protein-protein interaction networks have been
investigated with degree distributions, motifs and modularity, k-cliques and loops. Dynamical properties of gene regulatory networks have been modeled by Kauffman networks or by differential equations. In this talk, after a brief discussion of recent work on network theory relevant to these biological systems, I will describe how to model the metabolism of a cellular organism under a steady state assumption. I will also present new methods and results on the optimization of metabolic functionality by tuning genetic interactions.