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Dynamic Light Scattering Microscope

Jonathan Celli, Brian Gregor (Department of Physics, Boston University)

A Dynamic Light Scattering Microscope has been built on the platform of an upright microscope. The instrument is a simplified and more robust form of a design using a phase telescope [1]. Calibration data from the diffusion of polystyrene spheres in water are in agreement with expected results and data has also been acquired from two complex biological molecules, Porcine Gastric Mucin and Matrigel. For both samples, data has been acquired by scattering from the gels as well as scattering from tracer particles (polystyrene spheres). In the latter case, information about the viscoelastic properties of the biological gels is obtained from studying the dynamics of the tracer particles. [1] P.D. Kaplan and D. A. Weitz, Light-Scattering Microscopy," Applied Optics, 38 4151-4157 (1999).