PROFESSOR BERNARD CHASAN
590 Commonwealth Avenue
Office: Room 213
Lab: Room 226
Spring 1999 Schedule
|PY138: Physics of Chance and Necessity
(click here for course homepage)
MWF 2:00pm -3:00pm
My research (in loose collaboration with Professors El-Batanouny, Willis, and Horacio Cantiello of Massachusetts General Hospital) is concerned with the molecule ACTIN, which is part of the mammalian muscle apparatus, but is also involved in a huge range of cellular motions. Preliminary results from far infrared spectra suggest the presence of structural water in actin fibers; we speculate that this polymer is held together by water mediated hydrogen bonds between the monomer units. Further work to study this is planned, including Raman spectroscopy. We are also in the early stages of atomic force microscopy studies of this fascinating molecule, including the conditions under which the fibers form biologically important bundles, the polymerization process itself, and its behavior in various solution environments.
an Actin protein filament, demonstrating the helical
pitch of the macromolecule's quaternary structure.
|Image of two actin
filaments laid side by side. As seen in the image,
interaction between the two fibers is clearly
*Click on image for full view*
|Both images were obtained with a Digital Instruments™ Dimension 3000 Atomic Force Microscope in tapping mode, while the actin was polymerized in a biological buffer.|