High-Throughput Detection and Sizing of Individual Low-Index Nanoparticles and Viruses for Pathogen Identification
Journal Article

Published: Sunday, November 21, 2010
Citation: ACS Nanoletters, Volume 10, Pages pp 4727–4731
AIP Permalink: http://ultra.bu.edu/papers/Single-virus-nanoletters.pdf

Authors (1 total): B. Goldberg

Abstract: Rapid,chip-scale,andcost-effectivesingleparticledetectionofbiologicalagentsisofgreatimportancetohumanhealth and national security. We report real-time, high-throughput detection and sizing of individual, low-index polystyrene nanoparticles and H1N1 virus. Our widefield, common path interferometer detects nanoparticles and viruses over a very large sensing area, orders of magnitude larger than competing techniques. We demonstrate nanoparticle detection and sizing down to 70 nm in diameter. We clearly size discriminate nanoparticles with diameters of 70, 100, 150, and 200 nm. We also demonstrate detection and size characterization of hundreds of individual H1N1 viruses in a single experiment.