BU Molecular Biophysics Laboratory
Welcome to the Molecular Biophysics Lab in the Physics Department at Boston University!

Our lab specializes in vibrational spectroscopy of microbial rhodopsins to study their molecular mechanism. Microbial rhodopsins are membrane proteins in microbes responsible for ion transport, energy transduction, signaling, etc. In response to absorbing light, many of these proteins pump ions, open an ion channel, etc.

Microbial rhodopsins are still of high interest, especially because of optogenetics. Optogenetics is one of the most actively investigated technique in neuroscience. Optogenetic rhodopsins are expressed in neurons, which can be activated or silenced using light illumination. This significantly improves on spatial and temporal specificity compared to the old method of electrical probes.

Although many optogenetic proteins are being used for variety of applications, their molecular mechanism is not well understood. Our lab utilizes vibrational spectroscopy to better understand the molecular mechanism of these proteins. More specifically, we use static and time-resolved UV/Vis spectroscopy, near-IR resonance Raman spectroscopy, and low-temperature and time-resolved FTIR difference spectroscopy. Please visit the research tab for more details.

Our office is located in SCI-236 with labs in SCI-234, 238, and 354. Please feel free to visit us any time! For specific personnel, please see the People tab.

Recent News
  • May 2017
    Dr. Adrian Yi is hooded at the PhD hooding ceremony!
  • April 2017
    Prof. Rothschild is inducted into the National Academy of Inventors!
    GtACR1 FTIR paper is published in Biochemistry.
    Adrian Yi succesfully defends his thesis.
  • December 2016
    Prof. Rothschild is elected to the National Academy of Inventors.
  • April 2016
    GtACR1 Raman paper published in Biochemistry.
  • February 2016
    Adrian Yi attends BPS 2016.
  • May 2015
    Dr. John Ogren is hooded at the PhD hooding ceremony!
  • April 2015
    Dr. John Ogren starts post doc position at MIT in Gabriela Schlau-Cohen's lab.
    John Ogren successfully defends his thesis.
  • March 2015
    CaChR1 FTIR paper published in The Journal of Biological Chemistry.
  • February 2015
    Adrian Yi successfully passes his preliminary oral exam.
    Adrian Yi attends BPS 2015.
  • December 2014
    CaChR1 80K FTIR paper published in Biochemistry.
  • May 2014
    CaChR1 Raman paper published in Biochemistry.