BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//RLASKEY//CALENDEROUS//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20261020T094542Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20070213T201500Z
DTEND:20070213T220000Z
UID:event65@bu.edu
URL:http://physics.bu.edu/internal/events/show/65
SUMMARY:DNA translocation\, diffusion and unzipping through a Nanopore: The
	 physics of polymers in a highly confined space
DESCRIPTION:Featuring Amit Meller\, Boston University\nHosted by: Shyamsund
	er Erramilli\n\nPart of the Physics Department Colloquia Series.\n\nMany bi
	ological processes involve linear translocation of long biopolymers\, such 
	as DNA or RNA through nanoscle pores. Examples are phage infection\, bacter
	ial conjugation\, etc. We study the translocation dynamics of poly-nucleic 
	acids through biological pores\, as well as artificial pores\, in vitro. An
	 electrical field is used to "thread" the biopolymers through a nanoscale p
	ore\, while the ion current flowing through the pore is used to probe the s
	ystem. Using a dynamic voltage control\, we can rapidly manipulate the elec
	tric field (and hence the force) applied on the DNA\, while it occupies the
	 pore. This allows us to study translocation dynamics with or without drift
	\, and to use the system to probe DNA-DNA or DNA-protein interactions. We f
	ind that the translocation kinetics is sequence-dependent due to strong int
	eractions between the channel and the DNA. More surprisingly\, directionali
	ty plays an important factor in the DNA motion\, even for homo-polymers. Na
	nopore physics is an emerging field\, which has begun to impact biophysics 
	and biotechnology\, with applications for ultra fast DNA sequencing and DNA
	-protein analyses.
LOCATION: \, \, 
STATUS:CONFIRMED
CLASS:PUBLIC
END:VEVENT
END:VCALENDAR