BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//RLASKEY//CALENDEROUS//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260917T194059Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20100423T160000Z
DTEND:20100423T170000Z
UID:event619@bu.edu
URL:http://physics.bu.edu/internal/events/show/619
SUMMARY:Direct Correlation of Protein Structure and Function By High-pressu
	re X-ray Crystallography
DESCRIPTION:Featuring Dr. Buz Barstow\, Wyss Institute\, Harvard University
	\nHosted by: Shyamsunder Erramilli\n\nPart of the Biophysics/Condensed Matt
	er Seminar Series.\n\nAbstract: Protein molecules are intricate systems who
	se functions are highly sensitive to external perturbations. However\, few 
	examples that directly correlate protein function with continuous\, progres
	sive sub-angstrom structural perturbations have been presented. In this tal
	k\, I will discuss how we used high-pressure X-ray crystallography and spec
	troscopy to link sub-angstrom changes in the structure of the Aequorea yell
	ow fluorescent protein Citrine to a fluorescence peak shift from yellow to 
	green. I will also discuss how subtle changes in the scaffold of the protei
	n under pressure suggest ways to precisely tune the active sites of enzymes
	 at the sub-angstrom level.
LOCATION: \, \, 
STATUS:CONFIRMED
CLASS:PUBLIC
END:VEVENT
END:VCALENDAR