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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260915T200533Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20100402T160000Z
DTEND:20100402T170000Z
UID:event603@bu.edu
URL:http://physics.bu.edu/internal/events/show/603
SUMMARY:Gelation of stomach mucus and its relevance to motility of the ulce
	r causing bacterium
DESCRIPTION:Featuring Rama Bansil\, Boston University\n\nPart of the Biophy
	sics/Condensed Matter Seminar Series.\n\nAbstract:\nIn this talk\, I will d
	escribe the underlying biophysical mechanisms involved in the remarkable ab
	ility of the mucus lining of the stomach for protecting the stomach from be
	ing digested by the acidic gastric juices that it secretes. These remarkabl
	e physical properties can be attributed to the presence of a high molecular
	 weight glycoprotein found in mucus\, called mucin\, which forms a gel unde
	r acidic pH preventing the acid from diffusing back. A model of gelation ba
	sed on the interplay of hydrophobic and electrostatic interactions will be 
	discussed. Molecular Dynamics simulation studies of folding and aggregation
	 of mucin domains provide further support for this model. \n\nIn the second
	 part of the talk I will address the question\, " How does H. Pylori\, the 
	bacterium that causes ulcers\, move across the mucus layer". Stay tuned for
	 the surprising answer.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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