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VERSION:2.0
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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260907T040648Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20091014T210000Z
DTEND:20091014T220000Z
UID:event526@bu.edu
URL:http://physics.bu.edu/internal/events/show/526
SUMMARY:Interfacial water and peptide adsorption
DESCRIPTION:Featuring Roland Netz\, Technical University of Munich\nHosted 
	by: Claudio Chamon\n\nPart of the Biophysics/Condensed Matter Seminar Serie
	s.\n\nAbstract:\nThe structural and dynamic properties of  water at solid s
	urfaces are relevant for many physico-chemical processes.\nInsight can be g
	ained from  all-atomistic simulations of interfacial water that nowadays re
	ach the experimentally\nrelevant length and time scales. This is demonstrat
	ed with a few examples:\n\ni) Hydrophobic surfaces in contact with water sh
	ow a pronounced depletion layer\nwith a thickness of a few Angstroms within
	 which the water density is highly reduced1.\nThis layer leads to unusual s
	tatic and kinetic properties including a finite slip length2.\nii) Many pol
	ypeptides readily adsorb on both hydrophobic and hydrophilic surfaces. Sing
	le molecule AFM experiments yield adsorption energies and point to an extre
	mely high\nmobility on hydrophobic surfaces. The dominant hydrophobic attra
	ction can be quantitatively explained with classical MD simulations includi
	ng explicit water. Both water structural effects and dispersion interaction
	s contribute to this solvation attraction3.\niii) The friction coefficient 
	of bound polymers is very low on hydrophobic substrates\, which is traced b
	ack to the presence of a vacuum  layer between substrate and water\, which 
	forms a lubricating cushion on which a polymer can glide. Conversely\, fric
	tion forces on hydrophilic substrates are large and make determining the eq
	uilibrium binding constant in computer simulations impossible.[4]\n\n[1] In
	terfacial Water at Hydrophobic and Hydrophilic Surfaces: Depletion versus A
	dsorption\,\n    J. Janecek and R.R. Netz\, Langmuir 23\, 8417 (2007) [2] W
	ater slippage versus contact angle: a quasi-universal relationship\,     D.
	M. Huang\, C. Sendner\, D. Horinek\, R.R. Netz\, and L. Bocquet\, Physical 
	Review Letters  (2008)\n[3] Peptide adsorption on a hydrophobic surface res
	ults from an interplay of solvation\, surface and intrapeptide forces\,    
	D. Horinek\, A. Serr\, M. Geisler\, T. Pirzer\, U. Slotta\, S. Q. Lud\, J. 
	A. Garrido\, T. Scheibel\, T. Hugel\, R. R. Netz\, PNAS 105\, 2842 (2008)\n
	[4] Polypeptide friction and adhesion on hydrophobic and hydrophilic surfac
	es: A molecular dynamics case study\,     A. Serr\, D. Horinek and R.R. Net
	z\, Journal of the American Chemical Society 130\, 12408 (2008)
LOCATION: \, \, 
STATUS:CONFIRMED
CLASS:PUBLIC
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