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VERSION:2.0
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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260831T080402Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20090910T193000Z
DTEND:20090910T203000Z
UID:event495@bu.edu
URL:http://physics.bu.edu/internal/events/show/495
SUMMARY:Cellular heterogeneity and cooperativity shape decision-making in t
	he immune system
DESCRIPTION:Featuring Dr. Ofer Feinerman\, Sloan-Kettering Cancer Research 
	Center\n\nPart of the Biophysics/Condensed Matter Seminar Series.\n\nAbstra
	ct:\nCellular diversity\, flexibility and robustness are crucial features o
	f a \nreliable immune system\, in particular in the case of T lymphocytes \
	nenforcing antigen discrimination. We combined computational modeling and \
	nexperimental measurements at the single cell level to demonstrate how \nT-
	cells are highly variable in their sensitivity because of \nheterogeneity o
	f their protein expression. However\, we also discovered \nhow cell-cell in
	teractions proofread individual cell activation\, correct \ncellular noise 
	and restore reliability of the immune response at the \nsystem level. Speci
	fically we tested how IL2-mediated quorum sensing \nregulates rare sporadic
	 activation while remaining vulnerable to large \nscale 'systematic errors'
	 and demonstrated the role of IL2 depletion by \nregulatory T cells in the 
	suppression of weakly activated effector \ncells. Our work demonstrates tha
	t cell-cell dynamical feedback networks \nare integrated over heterogeneous
	 populations to achieve reliable \ndecision-making in the immune system.
LOCATION:PRB 595\, 3 Cummington Mall\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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