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VERSION:2.0
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CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260814T124135Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20090904T160000Z
DTEND:20090904T170000Z
UID:event488@bu.edu
URL:http://physics.bu.edu/internal/events/show/488
SUMMARY:Target location by proteins - typical vs. average times
DESCRIPTION:Featuring Yariv Kafri\, Technion\, Israel\nHosted by: Anatoli P
	olkovnikov\n\nPart of the Biophysics/Condensed Matter Seminar Series.\n\nAb
	stract:\n\nGenomic expression depends critically both on the ability of reg
	ulatory proteins to locate specific target sites on a DNA within seconds an
	d on the formation of long lived (many minutes) complexes between these pro
	teins and the DNA. Equilibrium experiments show that indeed regulatory prot
	eins bind tightly to their target site. However\, they also find strong bin
	ding to other non-specific sites which act as traps that can dramatically i
	ncrease the time needed to locate the target. This gives rise to a conflict
	 between the speed and stability requirements. In this tal a simple mechani
	sm which can resolve this long-standing paradox will be suggested.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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