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BEGIN:VEVENT
DTSTAMP:20260815T092814Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20090417T160000Z
DTEND:20090417T170000Z
UID:event426@bu.edu
URL:http://physics.bu.edu/internal/events/show/426
SUMMARY: Studying the effects of tumor microenvironment on migration\, asse
	mbly and therapeutic efficacy in a 3D model of ovarian cancer
DESCRIPTION:Featuring Dr. Jon Celli\, Wellman Center for Photomedicine\, MG
	H\, Harvard Medical School\nHosted by: Ophelia Tsui\n\nPart of the Biophysi
	cs/Condensed Matter Seminar Series.\n\nAbstract:\nThree-dimensional cell cu
	lture models\, which more accurately reflect the mechanical and architectur
	al properties of tumor microenvironment than traditional monolayer cultures
	\, have recently received considerable attention as physiologically relevan
	t systems to study tumor biology and therapeutic efficacy.  We have develop
	ed a model system in which ovarian cancer cells seeded on a basement membra
	ne matrix spontaneously migrate and assemble to form heterogeneous populati
	ons of micronodules resembling disseminated ovarian cancer.  In preliminary
	 studies of cells grown on Growth Factor Reduced Matrigel™ we have analyz
	ed growth kinetics using custom image processing routines to obtain informa
	tion on the size and shape of thousands of acini obtained from sets of sequ
	ential images.  We have consistently found that 3D nodules exhibit dramatic
	ally different growth kinetics and response to treatment as compared to mon
	olayer cells.   3D model systems also provide a unique platform to study th
	e influence of mechanical properties of the tumor stroma on the growth and 
	development of cancer cells.  Using customizable nanofiber scaffolds we are
	 exploring the role of specific matrix components such as laminin and fibro
	nectin on the mechanical properties of the tumor microenvironment and the i
	nfluence of these parameters on the growth\, motility and response to treat
	ment of 3D structures.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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