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VERSION:2.0
PRODID:-//RLASKEY//CALENDEROUS//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260825T002157Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20090403T153000Z
DTEND:20090403T163000Z
UID:event424@bu.edu
URL:http://physics.bu.edu/internal/events/show/424
SUMMARY:Self-assembly of rod-like polyelectrolytes: from materials to cysti
	c fibrosis
DESCRIPTION:Featuring Erik Luijten\, Northwestern University\nHosted by: Wi
	lliam Klein\n\nPart of the Biophysics/Condensed Matter Seminar Series.\n\nA
	bstract: Electrostatic interactions play an important role in many biologic
	al problems and can lead to counterintuitive phenomena. I will highlight a 
	number of problems in this area that we have addressed by means of computat
	ional methods. Specifically\, we have used Monte Carlo and molecular dynami
	cs simulations to better understand the self-assembly of stiff polyelectrol
	ytes (charged polymers). Such molecules\, e.g. filamentous actin\, form clo
	se-packed bundles in the presence of multivalent ions or proteins. We eluci
	date the mechanism of this self-assembly process and are able to make direc
	t comparison to experimental results obtained via small-angle x-ray scatter
	ing. I will also demonstrate how these findings pertain to fighting bacteri
	al infections in cystic fibrosis patients.
LOCATION:PRB 595\, 3 Cummington Mall\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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