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VERSION:2.0
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CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260917T194059Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20080305T163000Z
DTEND:20080305T173000Z
UID:event254@bu.edu
URL:http://physics.bu.edu/internal/events/show/254
SUMMARY:The forces which stabilize small functional RNAs
DESCRIPTION:Featuring Sebastian Doniach\, Stanford University\n\nPart of th
	e Biophysics/Condensed Matter Seminar Series.\n\nAbstract: So called non-co
	ding regions of genomes are increasingly being shown to code for various fu
	nctional RNA molecules which act as control elements in gene expression. Be
	cause of the charged nature of polynucleotides\, understanding how these fo
	ld into 3 dimensional functional forms requires a quantitative computation 
	of the energetics of the stabilizing counter ion cloud\, usually of magnesi
	um ions. Small angle x-ray scattering measurements of conformational change
	s as a function of ion concentration allow for estimates of the counter-ion
	 induced shielding of the repulsive forces and stabilization of the hydroge
	n bonding which defines the tertiary fold of the RNA. These will be discuss
	ed in the context of the folding of small ribozymes and riboswitches.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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