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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260812T023312Z
LAST-MODIFIED:20200311T185820Z
DTSTART:20200331T193000Z
DTEND:20200331T203000Z
UID:event2264@bu.edu
URL:http://physics.bu.edu/internal/events/show/2264
SUMMARY:Broken Time Reversal Symmetry and the Efficiency of Biological Mach
	ines
DESCRIPTION:Featuring Michael Murrell \, Yale University\nHosted by: Kirill
	 Korolev\nPoster: http://physics.bu.edu/internal//files/download/Murrell-Po
	ster.pdf\n\nPart of the Physics Department Colloquia Series.\n\nBiological 
	systems are driven far from equilibrium through the consumption and dissipa
	tion of energy.  However\, it is unclear if the quality or efficiency of a 
	biological process is enhanced the further the system is driven from equili
	brium.  To address this fundamental question\, we develop experimental appr
	oaches to control the consumption of energy in biological systems\, and the
	oretical approaches to measure its dissipation.  Together\, we gain an unde
	rstanding of the regulation of energy during the assembly and performance o
	f biological machinery across diverse time and length-scales.  At the molec
	ular scale\, we develop technologies to precisely coordinate the de novo as
	sembly of the protein-based mechanical machinery of the cell and control it
	s consumption of chemical energy.  In doing so\, we seek to mimic the physi
	cal behaviors of living cells through modulating the internal\, non-equilib
	rium "activity" in a non-living system.  We then apply frameworks from stoc
	hastic thermodynamics to estimate the production of entropy using phase spa
	ce fluxes and the breaking of time reversal symmetry.  At the mesoscopic sc
	ale\, we study the physical behaviors of cells and tissues by abstracting t
	hem as driven liquids\, whose behaviors are described by models of capillar
	ity and wetting adapted to reflect activity gleaned from molecular studies.
	  Together\, these experimental and theoretical methods can enable an under
	standing of the relationship between dissipation and the efficiency of biol
	ogical processes with significant impacts on phenotypic outcomes such as ca
	ncer metastasis\, and wound healing.
LOCATION:SCI 109\, 590 Commonwealth Avenue\, 02215
STATUS:CANCELLED
CLASS:PUBLIC
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