BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//RLASKEY//CALENDEROUS//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20261019T011022Z
LAST-MODIFIED:20191206T211946Z
DTSTART:20191212T170000Z
DTEND:20191212T180000Z
UID:event2250@bu.edu
URL:http://physics.bu.edu/internal/events/show/2250
SUMMARY:Heterogeneous Connectivity in E/I Network Allows Entrainment to a W
	ide  Range of Frequencies
DESCRIPTION:Featuring Jingjin Wei\n\nPart of the Preliminary Oral Exam.\n\n
	Examining Committee: Nancy Kopell\, Michelle McCarthy\, Rama Bansil\, Anush
	ya Chandran\n\nAbstract:\nNetworks of excitatory (E) and inhibitory (I) neu
	rons can produce rhythms and react to input with spectral content in multip
	le ways. Homogeneous PING networks are a type of E/I networks that produce 
	robust gamma rhythms without noise. They can be entrained only to a narrow 
	range of frequencies of a subthreshold periodic input. Here we investigate 
	the response of such networks to subthreshold periodic input in the presenc
	e of noise and heterogeneity. Our focus is on understanding which features 
	of the target network and the input allow for a large frequency range of en
	trainment by the periodic input. The target network consists of single comp
	artment neurons modeled with the spiking currents (Na+\, K+\, leak) and wit
	h Hodgkin-Huxley-type conductances. The network has a tonic external input 
	that generates a robust natural gamma rhythm at about 40-50 Hz.  White nois
	e is added to the E population. Heterogeneity is added in the AMPA synaptic
	 conductance from E to I. We find that noise helps entrain a population of 
	E cells: Without noise\, the E population exhibits a resonance effect only 
	when the input frequency is within 5Hz around the natural frequency. When n
	oise is added the E population can be entrained to a much wider frequency r
	ange. However\, in a PING network with feed-back inhibition from the I popu
	lation\, noise is not enough. With both noise to E population and heterogen
	eity in AMPA synaptic conductance from E to I added\, we show that\, for a 
	wide range of input frequencies (~ 8 to 10-fold increase)\, the network can
	 be entrained.  We identify a novel mechanism for entrainment that involves
	 frequency-dependent subgroups of I cells that are phase-locked to the inpu
	t frequencies; those phase-locked I cells in turn strengthen the entrainmen
	t.
LOCATION:MCS 279\, \, 
STATUS:CONFIRMED
CLASS:PUBLIC
END:VEVENT
END:VCALENDAR