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VERSION:2.0
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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20261024T174556Z
LAST-MODIFIED:20190207T184030Z
DTSTART:20190322T160000Z
DTEND:20190322T170000Z
UID:event2088@bu.edu
URL:http://physics.bu.edu/internal/events/show/2088
SUMMARY:Study of protein corona for polymeric drug delivery systems
DESCRIPTION:Featuring Sergey Filippov\, Harvard University\nHosted by: Rama
	 Bansil\n\nPart of the Biophysics/Condensed Matter Seminar Series.\n\nPolym
	er drug carriers based on N-(2-Hydroxypropyl)methacrylamide (HPMA) copolyme
	rs bearing cholesterol moieties have been studied extensively over the past
	 few years\, to understand the aggregation behavior and shape of the copoly
	mers in dilute aqueous solutions [1\,2]. Above certain concentration\, mice
	lle-like nanoparticles (NPs) having ellipsoidal shape are observed. However
	\, there is a lack of knowledge on the behavior of these drug carriers in h
	uman blood environment. Human serum albumin (HSA)\, fibrinogen\, Imunoglobu
	lin G\, and apolipoproteins A-E were chosen for this study as basic protein
	s\, which are the main component of human blood plasma. We use fluorescence
	 life-time correlation spectroscopy (FLCS)\, Electron Paramagnetic Resonanc
	e (EPR)\, isothermal titration calorimetry (ITC)\, nuclear magnetic resonan
	ce (NMR)\,  and small angle X-ray scattering (SAXS) to investigate HPMA cop
	olymers that are dissolved in an aqueous solution of proteins to reveal the
	 interaction between the NPs and proteins [3\,4].\n\n[1] S. K. Filippov\, e
	t al.\, Biomacromolecules\, 2012\, 13\, 2594\n[2] S. K.Filippov\, et al.\, 
	Biomacromolecules\, 2013\, 14\, 4061\n[3]   Xiaohan Zhang\, \,\,\, Sergey K
	. Filippov\, Christine M. Papadakis\, Langmuir\, 2018\, 34 (27)\, 7998-8006
	.\n[4]  Damir Klepac\,\,\,\,\, Sergey K. Filippov\,  Nanoscale\,  2018\, 10
	(13)\, 6194-6204.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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