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DTSTAMP:20260828T234017Z
LAST-MODIFIED:20180730T145543Z
DTSTART:20180731T160000Z
DTEND:20180731T170000Z
UID:event2004@bu.edu
URL:http://physics.bu.edu/internal/events/show/2004
SUMMARY:Efficacy of HIV Antibodies: Why Two Arms are Better than One
DESCRIPTION:Featuring Tal Einav\, Caltech\n\nPart of the Biophysics Seminar
	s.\n\nOne important pathway used to mount an effective immune response agai
	nst pathogens begins when antibodies tightly bind to invading particles. Ig
	G antibodies usually accomplish this by simultaneously binding two antigen-
	binding arms (Fabs) if one Fab dissociates\, IgGs can remain attached throu
	gh the second arm\, allowing the Fab to quickly reassociate. HIV foils this
	 strategy by only having a few highly-separated Envelope spikes (Envs) on i
	ts surface for IgGs to bind. This forces antibodies to bind monovalently\, 
	causing IgGs to rapidly dissociate which mitigates the immune response. To 
	counter this strategy\, we explore the efficacies of an array of synthetic 
	antibodies that vary in size and flexibility. We create a model that transl
	ates the geometry of each antibody into its neutralization potency and util
	ize it to theoretically design an optimal bivalent antibody to target HIV.
LOCATION:SCI 328\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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