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BEGIN:VEVENT
DTSTAMP:20261021T134801Z
LAST-MODIFIED:20180320T160927Z
DTSTART:20180326T163000Z
DTEND:20180326T173000Z
UID:event1891@bu.edu
URL:http://physics.bu.edu/internal/events/show/1891
SUMMARY:"High-throughput 3D tracking enables multiscale analysis of bacteri
	al motility behavior"
DESCRIPTION:Featuring Katja Taute\, Rowland Institute at Harvard\nHosted by
	: Kirill Korolev\n\nPart of the Biophysics Seminars.\n\nMany bacteria move 
	by rotating helical appendages called flagella\, but species differ widely 
	in the number\, position and shape of these flagella. The natural habitats 
	of motile bacteria are similarly diverse\, ranging from aqueous solutions s
	uch as oceans and lakes to complex environments such as mucus or soil. What
	 motility behaviors are enabled by different flagellar architectures? Which
	 behaviors are advantageous in which environments? Our lab strives to learn
	 how physics and ecology interplay in shaping the natural selection of bact
	erial motility strategies.\n\nWe are exploiting a recently developed high-t
	hroughput 3D tracking method that facilitates the rapid and label-free beha
	vioral phenotyping of large bacterial populations to understand how flagell
	ar architecture\, exemplified by select species and mutants\, affects motil
	ity behavior and chemotaxis in different environments\, on scales from indi
	viduals to populations. By combining 3D tracking with microfluidically gene
	rated gradients\, we can directly determine chemotactic drift velocities in
	 different types of environments\, such as hydrogels\, while simultaneously
	 resolving motility patterns and their modification in response to the grad
	ient. The combination of substantial statistical power for precisely discer
	ning population averages of traits with simultaneous knowledge of each indi
	vidual’s behavior enables a multiscale analysis connecting the two levels
	 and provides unprecedented access to a mechanistic understanding of divers
	e chemotactic mechanisms.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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