BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//RLASKEY//CALENDEROUS//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260813T225211Z
LAST-MODIFIED:20171205T143400Z
DTSTART:20171206T173000Z
DTEND:20171206T183000Z
UID:event1871@bu.edu
URL:http://physics.bu.edu/internal/events/show/1871
SUMMARY:"The mode and predictability of intra-tumour evolution"
DESCRIPTION:Featuring Rob Noble\, ETH Zürich\n\nPart of the Biophysics Sem
	inars.\n\nIntra-tumour genetic heterogeneity is a product of evolution in s
	patially structured populations of cells. Whereas genetic heterogeneity has
	 been proposed as a prognostic biomarker in cancer\, its spatially dynamic 
	nature makes accurate prediction of tumor progression challenging. Progress
	ing from the Eden growth model to spatial versions of the Moran process\, I
	 will characterize how tissue architecture influences the potential for sub
	clonal population growth\, the prevalence of clonal sweeps\, and the result
	ing pattern of intratumour heterogeneity. Based on computational simulation
	s\, I will further describe the conditions under which genetic diversity is
	 most predictive of future tumour states. These findings help explain the m
	ultiformity of tumour evolution and contribute to establishing a theoretica
	l foundation for predictive oncology.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
END:VEVENT
END:VCALENDAR