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DTSTAMP:20260831T100609Z
LAST-MODIFIED:20171120T184031Z
DTSTART:20171128T173000Z
DTEND:20171128T183000Z
UID:event1834@bu.edu
URL:http://physics.bu.edu/internal/events/show/1834
SUMMARY:"Design\, control\, and applications of DNA nanomechanical devices"
DESCRIPTION:Featuring Carlos Castro \, Ohio State University \nHosted by: M
	aria Kamenetska\n\nPart of the Biophysics Seminars.\n\nStructural DNA nanot
	echnology is a rapidly emerging field with exciting potential for applicati
	ons such as single molecule sensing\, drug delivery\, and manipulating mole
	cular components. However\, realizing the functional potential of DNA nanom
	achines\, and ultimately nanorobots\, requires the ability to design dynami
	c mechanical behavior such as complex motion\, conformational dynamics\, or
	 force generation. Our lab has developed approaches to design and construct
	 DNA nanostructures with programmable 1D\, 2D\, and 3D motion as well as dy
	namic nanostructures with programmed or externally controlled conformationa
	l dynamics. We have also recently developed methods to manipulate dynamic D
	NA nanodevices via external magnetic fields. This approach relies on coupli
	ng the motion of micron-scale magnetic beads to nanoscale DNA machines via 
	a long mechanical lever arm made from an array of highly stiff DNA origami 
	structures. We demonstrated the ability to drive continuous or oscillating 
	rotational motions of nanoscale devices up to several Hz. Moving forward\, 
	we aim to develop devices where nanoscale dynamic behavior (i.e. motion\, c
	onformational distributions\, and kinetics) can be exploited to probe physi
	cal properties or manipulate nanoscale components or molecular interactions
	 in real time. I will also highlight two ongoing projects in our lab implem
	enting DNA nanodevices to probe the structure and dynamics of nucleosomes a
	nd to engineer cell surface functions such as intercellular adhesion and bi
	omolecule sensing.
LOCATION:RKC 106B\, 610 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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