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BEGIN:VEVENT
DTSTAMP:20261018T100634Z
LAST-MODIFIED:20130501T205128Z
DTSTART:20130509T180000Z
DTEND:20130509T190000Z
UID:event1108@bu.edu
URL:http://physics.bu.edu/internal/events/show/1108
SUMMARY:Study of Striatal Cholinergic System in Parkinson’s Disease by Op
	togenetics
DESCRIPTION:Featuring Xuan Gu\n\nPart of the Preliminary Oral Exam.\n\nExam
	ining committee: Kenneth Rothschild\, Tulika Bose\, Nancy Kopell (Math Dept
	)\, Xue Han (BME)\n\nAbstract:\n\nParkinson's Disease is a neurodegenerativ
	e disorder affecting over five million people around the world. PD patients
	 experience devastating motor deficits\, such as bradykinesia (slowness of 
	movement)\, tremor\, and rigidity. Our lab has pioneered optogenetics\, a n
	ovel neurotechnology using light and genetic methods to control specific ne
	urons in the brain. Combining optogenetics with classical electrophysiology
	 to record neural signals\, while activating or silencing different brain c
	ells with light\, we can identify specific brain activities responsible for
	 certain behavioral phenomena. Using these tools\, I am examining the causa
	l role of different neural network elements in PD pathology. By optogenetic
	ally silencing and stimulating neurons in transgenic mice optogentic protei
	ns\, I am studying whether the strong ‘brain-wave’ oscillation between 
	10Hz and 30Hz\, known as "beta oscillation"\, is responsible for PD motor d
	eficit\, and whether suppressing beta oscillations is responsible for the t
	herapeutic effect of deep brain stimulation (DBS)\, an emerging effective t
	reatment for PD.
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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