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DTSTAMP:20260913T121127Z
LAST-MODIFIED:20121116T203436Z
DTSTART:20070427T173000Z
DTEND:20070427T183000Z
UID:event108@bu.edu
URL:http://physics.bu.edu/internal/events/show/108
SUMMARY:Dynamics of Microtubule Growth and Catastrophe
DESCRIPTION:Featuring Sid Redner\, Boston University\n\nPart of the Biophys
	ics/Condensed Matter Seminar Series.\n\nWe investigate a simple model of mi
	crotubule dynamics in which a microtubule evolves by: (i) attachment of gua
	nosine triphosphate (GTP) to its end at rate lambda\, (ii) irreversible con
	version of GTP to guanosine diphosphate (GDP) at rate 1\, and (iii) detachm
	ent of GDP from the microtubule end at rate mu.  As a function of these ele
	mental rates\, a microtubule can grow steadily or its length can fluctuate 
	wildly.  A master equation approach is developed to characterize these rich
	 features.  For mu=0\, we find the exact tubule and GTP cap length distribu
	tions\, as well as power-law length distributions of GTP and GDP islands.  
	For mu=oo\, we find the average time between catastrophes\, where the micro
	tubule shrinks to zero length\, and the size distribution of avalanches (se
	quence of consecutive GDP detachment events).\n\nwork in collaboration with
	 T. Antal\, P. Krapivsky\, B. Chakraborty\, and M. Mailman
LOCATION:SCI 352\, 590 Commonwealth Avenue\, 02215
STATUS:CONFIRMED
CLASS:PUBLIC
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